Version 5.4
Mus musculus Gene: Gsr
Summary
InnateDB Gene IDBG-147832.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gsr
Gene Name glutathione reductase
Synonyms AI325518; D8Ertd238e; Gr-1; Gr1
Species Mus musculus
Ensembl Gene ENSMUSG00000031584
Encoded Proteins
IDBP-147834
glutathione reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104687:
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:33652523-33698163
Strand Forward strand
Band A3
Transcripts
ENSMUST00000033992 ENSMUSP00000033992
ENSMUST00000154745
ENSMUST00000149528
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004362 glutathione-disulfide reductase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104687
View Gene Order
ENSBTAG00000007115
Not yet available
Pathways
NETPATH
REACTOME
REACT_238368
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_188957
Cellular responses to stress pathway
REACT_189141
Detoxification of Reactive Oxygen Species pathway
REACT_188937
Metabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00480
Glutathione metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00480
Glutathione metabolism pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.283573 Mm.490494
RefSeq NM_010344
OMIM
CCDS CCDS22235
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca