Version 5.4
Mus musculus Protein: Gsr
Summary
InnateDB Protein IDBP-147834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gsr
Protein Name glutathione reductase
Synonyms AI325518; D8Ertd238e; Gr-1; Gr1;
Species Mus musculus
Ensembl Protein ENSMUSP00000033992
InnateDB Gene IDBG-147832 (Gsr)
Protein Structure
UniProt Annotation
Function Maintains high levels of reduced glutathione in the cytosol.
Subcellular Localization Isoform Mitochondrial: Mitochondrion.Isoform Cytoplasmic: Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004362 glutathione-disulfide reductase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:95804
InterPro IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR000815 Mercuric reductase
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
IPR006322 Glutathione reductase, eukaryote/bacterial
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
PFAM PF00070
PF02852
PF07992
PRINTS PR00469
PR00945
PR00368
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47791
PhosphoSite PhosphoSite-P47791
TrEMBL Q91Z57
UniProt Splice Variant
Entrez Gene 14782
UniGene Mm.490494
RefSeq NP_034474
MGI ID
MGI Symbol Gsr
OMIM
CCDS CCDS22235
HPRD
IMGT
EMBL AK040136 AK084328 AK151697 BC006966 BC056357 BC057325 X76341
GenPept AAH06966 AAH56357 AAH57325 BAC30518 BAC39162 BAE30621 CAA53959

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca