InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map4k4

Summary

InnateDB Gene

IDBG-147835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map4k4

Gene Name

mitogen-activated protein kinase kinase kinase kinase 4

Synonyms

9430080K19Rik; AU043147; AU045934; AW046177; HGK; Nik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026074

Encoded Proteins

IDBP-625818

mitogen-activated protein kinase kinase kinase kinase 4

IDBP-625819

mitogen-activated protein kinase kinase kinase kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071054:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:39900913-40026310

Strand

Forward strand

Band

Transcripts

ENSMUST00000163854	ENSMUSP00000126961
ENSMUST00000168431	ENSMUSP00000129796

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0010977	negative regulation of neuron projection development
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0046328	regulation of JNK cascade
GO:0050790	regulation of catalytic activity
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070571	negative regulation of neuron projection regeneration

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000071054

View Gene Order

ENSBTAG00000013023

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

ceramide_pathway

Ceramide signaling pathway

p53downstreampathway

Direct p53 effectors

ephbfwdpathway

EPHB forward signaling

Cross-References

SwissProt

TrEMBL

F8VPL5 Q3UTY9

UniProt Splice Variant

Entrez Gene

26921

UniGene

Mm.19073 Mm.415149 Mm.489066

RefSeq

NM_001252200 NM_001252201 NM_008696 NM_001252202

OMIM

CCDS

CCDS35546

HPRD

IMGT

MGI ID

MGI:1349394

MGI Symbol

Map4k4

EMBL

AC132909 AC166238 AK138966

GenPept

BAE23840

RNA Seq Atlas

26921