Version 5.4
Bos taurus Gene: MAP4K4
Summary
InnateDB Gene IDBG-630617.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4K4
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013023
Encoded Proteins
IDBP-682229
mitogen-activated protein kinase kinase kinase kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071054:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6610556-6660137
Strand Forward strand
Band
Transcripts
ENSBTAT00000006458 ENSBTAP00000006458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000071054
View Gene Order
ENSMUSG00000026074
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
p53downstreampathway
Direct p53 effectors
ephbfwdpathway
EPHB forward signaling
Cross-References
SwissProt
TrEMBL F1MI60
UniProt Splice Variant
Entrez Gene
UniGene Bt.111711 Bt.112160 Bt.59199
RefSeq
HUGO HGNC:6866
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030224
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca