Version 5.4
Mus musculus Gene: March3
Summary
InnateDB Gene IDBG-148017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March3
Gene Name membrane-associated ring finger (C3HC4) 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032656
Encoded Proteins
IDBP-148019
membrane-associated ring finger (C3HC4) 3
IDBP-148021
membrane-associated ring finger (C3HC4) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173926:
MARCH3 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH3 appears to function in the endosomal recycling pathway (Fukuda et al., 2006 [PubMed 16428329]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:56761716-56925548
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000102912 ENSMUSP00000099976
ENSMUST00000035278 ENSMUSP00000047946
ENSMUST00000153044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000173926
View Gene Order
ENSBTAG00000006797
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.312623
RefSeq NM_177115
OMIM
CCDS CCDS29262
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca