Version 5.4
Homo sapiens Gene: MARCH3
Summary
InnateDB Gene IDBG-39523.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH3
Gene Name membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173926
Encoded Proteins
IDBP-39525
membrane-associated ring finger (C3HC4) 3
IDBP-475034
membrane-associated ring finger (C3HC4) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MARCH3 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH3 appears to function in the endosomal recycling pathway (Fukuda et al., 2006 [PubMed 16428329]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:126867714-127030808
Strand Reverse strand
Band q23.2
Transcripts
ENST00000308660 ENSP00000309141
ENST00000506088
ENST00000504239
ENST00000515241 ENSP00000421979
ENST00000502289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0016567 protein ubiquitination
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032656
View Gene Order
ENSBTAG00000006797
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.132441 Hs.603835
RefSeq NM_178450
HUGO
OMIM
CCDS CCDS4141
HPRD 14362
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca