InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: F9

Summary

InnateDB Gene

IDBG-148025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

coagulation factor IX

Synonyms

AW111646; Cf-9; Cf9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031138

Encoded Proteins

IDBP-148027

coagulation factor IX

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101981:
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:59999464-60030759

Strand

Forward strand

Band

Transcripts

ENSMUST00000033477

ENSMUSP00000033477

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity