InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F9

Summary

InnateDB Gene

IDBG-87825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

coagulation factor IX

Synonyms

FIX; HEMB; P19; PTC; THPH8

Species

Homo sapiens

Ensembl Gene

ENSG00000101981

Encoded Proteins

IDBP-87827

coagulation factor IX

IDBP-242301

coagulation factor IX

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:139530758-139563458

Strand

Forward strand

Band

q27.1

Transcripts

ENST00000218099	ENSP00000218099
ENST00000394090	ENSP00000377650
ENST00000479617

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0007598	blood coagulation, extrinsic pathway
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process