Version 5.4
Mus musculus Gene: Megf10
Summary
InnateDB Gene IDBG-148090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Megf10
Gene Name multiple EGF-like-domains 10
Synonyms 3000002B06Rik; Gm331
Species Mus musculus
Ensembl Gene ENSMUSG00000024593
Encoded Proteins
IDBP-148092
multiple EGF-like-domains 10
IDBP-538488
multiple EGF-like-domains 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145794:
This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:57133090-57297467
Strand Forward strand
Band D3
Transcripts
ENSMUST00000075770 ENSMUSP00000075174
ENSMUST00000139892 ENSMUSP00000116814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0014719 satellite cell activation
GO:0014816 satellite cell differentiation
GO:0014841 satellite cell proliferation
GO:0034109 homotypic cell-cell adhesion
GO:0043654 recognition of apoptotic cell
GO:0048641 regulation of skeletal muscle tissue development
GO:0051147 regulation of muscle cell differentiation
GO:0055001 muscle cell development
Cellular Component
GO:0001891 phagocytic cup
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145794
View Gene Order
ENSBTAG00000000329
Not yet available
Cross-References
SwissProt
TrEMBL Z4YM36
UniProt Splice Variant
Entrez Gene 70417
UniGene Mm.297863
RefSeq NM_001001979
OMIM
CCDS CCDS29264
HPRD
IMGT
MGI ID MGI:2685177
MGI Symbol Megf10
EMBL AC102173 AC152396 AC157904
GenPept
RNA Seq Atlas 70417

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca