Version 5.4
Mus musculus Gene: Fbn2
Summary
InnateDB Gene IDBG-148594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbn2
Gene Name fibrillin 2
Synonyms BC063774; Fib-2; mKIAA4226; sne; sy
Species Mus musculus
Ensembl Gene ENSMUSG00000024598
Encoded Proteins
IDBP-148596
fibrillin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138829:
The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:58008623-58209926
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000025497 ENSMUSP00000025497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0030326 embryonic limb morphogenesis
GO:0030501 positive regulation of bone mineralization
GO:0035108 limb morphogenesis
GO:0035583 sequestering of TGFbeta in extracellular matrix
GO:0045669 positive regulation of osteoblast differentiation
GO:0060346 bone trabecula formation
Cellular Component
GO:0001527 microfibril
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000138829
View Gene Order
Pathways
NETPATH
REACTOME
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_206066
Extracellular matrix organization pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q61555
TrEMBL
UniProt Splice Variant
Entrez Gene 14119
UniGene Mm.20271
RefSeq NM_010181 XM_006544495
OMIM
CCDS CCDS37827
HPRD
IMGT
MGI ID MGI:95490
MGI Symbol Fbn2
EMBL AC102317 AC127358 L39790 S69359
GenPept AAA74908 AAC60685
RNA Seq Atlas 102642295 14119

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca