InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbn2

Summary

InnateDB Protein

IDBP-148596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbn2

Protein Name

fibrillin 2

Synonyms

BC063774; Fib-2; mKIAA4226; sne; sy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025497

InnateDB Gene

IDBG-148594 (Fbn2)

Protein Structure

UniProt Annotation

Function

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. {ECO:0000269PubMed:20855508}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0030326	embryonic limb morphogenesis
GO:0030501	positive regulation of bone mineralization
GO:0035108	limb morphogenesis
GO:0035583	sequestering of TGFbeta in extracellular matrix
GO:0045669	positive regulation of osteoblast differentiation
GO:0060346	bone trabecula formation

Cellular Component

GO:0001527	microfibril
GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:95490

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011398 Fibrillin/Microneme protein4
IPR015919 Cadherin-like
IPR017878 TB domain

PFAM

PF00008
PF07645
PF00683

PRINTS

PIRSF

PIRSF036312

SMART

SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt