InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Klf4

Summary

InnateDB Gene

IDBG-148689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klf4

Gene Name

Kruppel-like factor 4 (gut)

Synonyms

EZF; Gklf; Zie

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003032

Encoded Proteins

IDBP-266279

Kruppel-like factor 4 (gut)

IDBP-536011

Kruppel-like factor 4 (gut)

IDBP-535593

Kruppel-like factor 4 (gut)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23733190

KLF4 mediates the repression of Ciita/MHC-II in M. bovis BCG infected macrophages to evade antigen presentation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136826:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:55527143-55532466

Strand

Reverse strand

Band

Transcripts

ENSMUST00000107619	ENSMUSP00000103245
ENSMUST00000129250	ENSMUSP00000116514
ENSMUST00000132746	ENSMUSP00000123687

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001010	sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001221	transcription cofactor binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035014	phosphatidylinositol 3-kinase regulator activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0009913	epidermal cell differentiation
GO:0010033	response to organic substance
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014740	negative regulation of muscle hyperplasia
GO:0019827	stem cell maintenance
GO:0030154	cell differentiation
GO:0031077	post-embryonic camera-type eye development
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032526	response to retinoic acid
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0035166	post-embryonic hemopoiesis
GO:0042127	regulation of cell proliferation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045444	fat cell differentiation
GO:0045595	regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046985	positive regulation of hemoglobin biosynthetic process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048730	epidermis morphogenesis
GO:0051247	positive regulation of protein metabolic process
GO:0051898	negative regulation of protein kinase B signaling
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071409	cellular response to cycloheximide
GO:0071499	cellular response to laminar fluid shear stress
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:1901653	cellular response to peptide
GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production