InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KLF4

Summary

InnateDB Gene

IDBG-79820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF4

Gene Name

Kruppel-like factor 4 (gut)

Synonyms

EZF; GKLF

Species

Homo sapiens

Ensembl Gene

ENSG00000136826

Encoded Proteins

IDBP-79822

Kruppel-like factor 4 (gut)

IDBP-377202

Kruppel-like factor 4 (gut)

IDBP-377206

Kruppel-like factor 4 (gut)

IDBP-807397

Kruppel-like factor 4 (gut)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23733190

[Mus musculus] KLF4 mediates the repression of Ciita/MHC-II in M. bovis BCG infected macrophages to evade antigen presentation.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:107484852-107490482

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000374672	ENSP00000363804
ENST00000411706	ENSP00000399921
ENST00000420475	ENSP00000404922
ENST00000497048
ENST00000493306
ENST00000610832	ENSP00000483629

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	37 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001010	sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001221	transcription cofactor binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0035014	phosphatidylinositol 3-kinase regulator activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007500	mesodermal cell fate determination
GO:0008285	negative regulation of cell proliferation
GO:0009913	epidermal cell differentiation
GO:0010033	response to organic substance
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014740	negative regulation of muscle hyperplasia
GO:0019827	stem cell maintenance
GO:0030154	cell differentiation
GO:0031077	post-embryonic camera-type eye development
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032526	response to retinoic acid
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0035166	post-embryonic hemopoiesis
GO:0042127	regulation of cell proliferation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045444	fat cell differentiation
GO:0045595	regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046985	positive regulation of hemoglobin biosynthetic process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048730	epidermis morphogenesis
GO:0050728	negative regulation of inflammatory response
GO:0051247	positive regulation of protein metabolic process
GO:0051898	negative regulation of protein kinase B signaling
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071409	cellular response to cycloheximide
GO:0071499	cellular response to laminar fluid shear stress
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:1901653	cellular response to peptide
GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003032

View Gene Order

ENSBTAG00000020355

Not yet available

Pathways

NETPATH

REACTOME

REACT_19189

Synthesis, secretion, and deacylation of Ghrelin pathway

REACT_27161

Transcriptional regulation of white adipocyte differentiation pathway

REACT_111045

Developmental Biology pathway

REACT_200812

Transcriptional regulation of pluripotent stem cells pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

INOH

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_004235

HUGO

OMIM

CCDS

CCDS6770

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas