Version 5.4
Mus musculus Gene: Lin28b
Summary
InnateDB Gene IDBG-148994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lin28b
Gene Name lin-28 homolog B (C. elegans)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000063804
Encoded Proteins
IDBP-148996
lin-28 homolog B (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187772:
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:45376620-45470201
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000079390 ENSMUSP00000078361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0010587 miRNA catabolic process
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187772
View Gene Order
ENSBTAG00000043973
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt Q45KJ6
TrEMBL
UniProt Splice Variant
Entrez Gene 380669
UniGene Mm.440328
RefSeq NM_001031772 XM_006512784
OMIM
CCDS CCDS35895
HPRD
IMGT
MGI ID MGI:3584032
MGI Symbol Lin28b
EMBL AC153847 AC155715 AK012973 AK133928 BC089037 DQ127225
GenPept AAH89037 AAZ38894 BAE21931 BAE43235
RNA Seq Atlas 380669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca