Version 5.4
Homo sapiens Gene: LIN28B
Summary
InnateDB Gene IDBG-94771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIN28B
Gene Name lin-28 homolog B (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187772
Encoded Proteins
IDBP-94773
lin-28 homolog B (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:104957048-105083332
Strand Forward strand
Band q16.3
Transcripts
ENST00000345080 ENSP00000344401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0010587 miRNA catabolic process
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063804
View Gene Order
ENSBTAG00000043973
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt Q6ZN17
TrEMBL A7E2T3
UniProt Splice Variant
Entrez Gene 389421
UniGene Hs.23616 Hs.607971
RefSeq NM_001004317 XM_006715477
HUGO HGNC:32207
OMIM 611044
CCDS CCDS34504
HPRD
IMGT
EMBL AK131411 AL135911 BC127712 BC127713 BC137526 BC137527 BC141960 BC150537 BC150538 CH471051 DQ127228 Z95329
GenPept AAI27713 AAI27714 AAI37527 AAI37528 AAI41961 AAI50538 AAI50539 AAZ38897 BAD18558 CAI20969 CAI21661 EAW48434
RNA Seq Atlas 389421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca