Version 5.4
Mus musculus Gene: Hace1
Summary
InnateDB Gene IDBG-149114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hace1
Gene Name HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038822
Encoded Proteins
IDBP-149116
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-539377
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-536957
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-537528
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 27213432
[Homo sapiens] HACE1 plays an inhibitory role in virus-induced signalling by disrupting the MAVS-TRAF3 complex.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085382:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:45577829-45712345
Strand Forward strand
Band B2
Transcripts
ENSMUST00000037044 ENSMUSP00000039206
ENSMUST00000131568 ENSMUSP00000121196
ENSMUST00000136905
ENSMUST00000142956
ENSMUST00000150511 ENSMUSP00000117985
ENSMUST00000131406 ENSMUSP00000118554
ENSMUST00000155368
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0017137 Rab GTPase binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007030 Golgi organization
GO:0007049 cell cycle
GO:0016567 protein ubiquitination
GO:0030334 regulation of cell migration
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0061025 membrane fusion
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000085382
View Gene Order
ENSBTAG00000001533
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 209462
UniGene Mm.404067 Mm.458633
RefSeq NM_172473 XM_006512639
OMIM
CCDS CCDS23829
HPRD
IMGT
MGI ID MGI:2446110
MGI Symbol Hace1
EMBL
GenPept
RNA Seq Atlas 209462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca