InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hace1

Summary

InnateDB Protein

IDBP-149116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hace1

Protein Name

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039206

InnateDB Gene

IDBG-149114 (Hace1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB. {ECO:0000250, ECO:0000269PubMed:19350571}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0017137	Rab GTPase binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007030	Golgi organization
GO:0007049	cell cycle
GO:0016567	protein ubiquitination
GO:0030334	regulation of cell migration
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0061025	membrane fusion
GO:0070936	protein K48-linked ubiquitination