Version 5.4
Mus musculus Gene: Rhoj
Summary
InnateDB Gene IDBG-149149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhoj
Gene Name ras homolog gene family, member J
Synonyms 1110005O19Rik; Arhj; AW210585; TC10L; TCL
Species Mus musculus
Ensembl Gene ENSMUSG00000046768
Encoded Proteins
IDBP-149151
ras homolog gene family, member J
IDBP-401478
ras homolog gene family, member J
IDBP-401477
ras homolog gene family, member J
IDBP-626493
ras homolog gene family, member J
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126785:
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:75308322-75401456
Strand Forward strand
Band C3
Transcripts
ENSMUST00000055390 ENSMUSP00000059498
ENSMUST00000118602 ENSMUSP00000112379
ENSMUST00000118966 ENSMUSP00000113165
ENSMUST00000146096
ENSMUST00000172981 ENSMUSP00000134552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0015031 protein transport
GO:0030036 actin cytoskeleton organization
GO:0061299 retina vasculature morphogenesis in camera-type eye
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126785
View Gene Order
ENSBTAG00000017200
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YX61 F2Z463
UniProt Splice Variant
Entrez Gene 80837
UniGene Mm.454096
RefSeq NM_023275
OMIM
CCDS CCDS25981
HPRD
IMGT
MGI ID MGI:1931551
MGI Symbol Rhoj
EMBL AC124414 AC141426
GenPept
RNA Seq Atlas 80837

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca