InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rhoj

Summary

InnateDB Protein

IDBP-149151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhoj

Protein Name

ras homolog gene family, member J

Synonyms

1110005O19Rik; Arhj; AW210585; TC10L; TCL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059498

InnateDB Gene

IDBG-149149 (Rhoj)

Protein Structure

UniProt Annotation

Function

GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology. {ECO:0000269PubMed:10967094}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in heart with moderate levels in lung and liver. Very low levels detected in brain, spleen, skeletal muscle, kidney and testis. {ECO:0000269PubMed:10967094}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0008360	regulation of cell shape
GO:0015031	protein transport
GO:0030036	actin cytoskeleton organization
GO:0061299	retina vasculature morphogenesis in camera-type eye

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1931551

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt