Version 5.4
Mus musculus Gene: Dek
Summary
InnateDB Gene IDBG-149348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dek
Gene Name DEK oncogene (DNA binding)
Synonyms 1810019E15Rik; D13H6S231E
Species Mus musculus
Ensembl Gene ENSMUSG00000021377
Encoded Proteins
IDBP-149350
DEK oncogene (DNA binding)
IDBP-532978
DEK oncogene (DNA binding)
IDBP-537658
DEK oncogene (DNA binding)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124795:
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:47084775-47106201
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000021807 ENSMUSP00000021807
ENSMUST00000138401
ENSMUST00000135278 ENSMUSP00000121663
ENSMUST00000129352 ENSMUSP00000114392
ENSMUST00000143933
ENSMUST00000150652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0042393 histone binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0016568 chromatin modification
GO:2000779 regulation of double-strand break repair
GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124795
View Gene Order
ENSBTAG00000012865
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.399617
RefSeq NM_025900
OMIM
CCDS CCDS26490
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca