Version 5.4
Bos taurus Gene: DEK
Summary
InnateDB Gene IDBG-635843.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEK
Gene Name protein DEK
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012865
Encoded Proteins
IDBP-687720
protein DEK
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124795:
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:39133610-39165303
Strand Forward strand
Band
Transcripts
ENSBTAT00000017097 ENSBTAP00000017097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0042393 histone binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:2000779 regulation of double-strand break repair
GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000124795
View Gene Order
ENSMUSG00000021377
View Gene Order
Cross-References
SwissProt
TrEMBL A5PJQ1
UniProt Splice Variant
Entrez Gene 540945
UniGene Bt.14295 Bt.70117
RefSeq NM_001099717
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142198 DAAA02055618
GenPept AAI42199
RNA Seq Atlas 540945

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca