Version 5.4
Mus musculus Gene: Notch1
Summary
InnateDB Gene IDBG-149571.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Notch1
Gene Name notch 1
Synonyms 9930111A19Rik; lin-12; Mis6; N1; Tan1
Species Mus musculus
Ensembl Gene ENSMUSG00000026923
Encoded Proteins
IDBP-149575
Notch gene homolog 1 (Drosophila)
IDBP-540383
Notch gene homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21737799
Notch1 signalling modulates the microglia innate response to post-ischemic brain damage inflammation. Notch1 deficient mice exhibit significantly lower levels of activated microglia and reduced proinflammatory cytokine expression.
InnateDB Annotation from Orthologs
Summary
PMID 21737799
[Homo sapiens] NOTCH1 signalling modulates the microglia innate response to post-ischemic brain damage inflammation. Notch1 deficient mice exhibit significantly lower levels of activated microglia and reduced proinflammatory cytokine expression. (Demonstrated in mouse)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148400:
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:26457903-26516663
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000028288 ENSMUSP00000028288
ENSMUST00000132941
ENSMUST00000147481
ENSMUST00000140082
ENSMUST00000126872
ENSMUST00000148948
ENSMUST00000138034
ENSMUST00000123873
ENSMUST00000129506
ENSMUST00000132820 ENSMUSP00000115258
ENSMUST00000131393
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 181 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 39 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 181 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004857 enzyme inhibitor activity
GO:0004872 receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001947 heart looping
GO:0002040 sprouting angiogenesis
GO:0002051 osteoblast fate commitment
GO:0002052 positive regulation of neuroblast proliferation
GO:0002437 inflammatory response to antigenic stimulus
GO:0003157 endocardium development
GO:0003160 endocardium morphogenesis
GO:0003162 atrioventricular node development
GO:0003169 coronary vein morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003192 mitral valve formation
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003207 cardiac chamber formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003213 cardiac right atrium morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003219 cardiac right ventricle formation
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003241 growth involved in heart morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003264 regulation of cardioblast proliferation
GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003273 cell migration involved in endocardial cushion formation
GO:0003344 pericardium morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007386 compartment pattern specification
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008544 epidermis development
GO:0009912 auditory receptor cell fate commitment
GO:0010001 glial cell differentiation
GO:0010468 regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010832 negative regulation of myotube differentiation
GO:0014031 mesenchymal cell development
GO:0014807 regulation of somitogenesis
GO:0021515 cell differentiation in spinal cord
GO:0021915 neural tube development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030279 negative regulation of ossification
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0031069 hair follicle morphogenesis
GO:0031100 organ regeneration
GO:0031960 response to corticosteroid
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0035116 embryonic hindlimb morphogenesis
GO:0035148 tube formation
GO:0035914 skeletal muscle cell differentiation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0042127 regulation of cell proliferation
GO:0042246 tissue regeneration
GO:0042640 anagen
GO:0043065 positive regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048103 somatic stem cell division
GO:0048663 neuron fate commitment
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0050768 negative regulation of neurogenesis
GO:0050793 regulation of developmental process
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0060271 cilium morphogenesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060548 negative regulation of cell death
GO:0060740 prostate gland epithelium morphogenesis
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0060842 arterial endothelial cell differentiation
GO:0060843 venous endothelial cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060956 endocardial cell differentiation
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0061344 regulation of cell adhesion involved in heart morphogenesis
GO:0061384 heart trabecula morphogenesis
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986 left/right axis specification
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0072017 distal tubule development
GO:0072044 collecting duct development
GO:0072144 glomerular mesangial cell development
GO:0072602 interleukin-4 secretion
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell maintenance
GO:1901189 positive regulation of ephrin receptor signaling pathway
GO:1901201 regulation of extracellular matrix assembly
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:2000737 negative regulation of stem cell differentiation
GO:2000811 negative regulation of anoikis
GO:2000974 negative regulation of pro-B cell differentiation
GO:2001027 negative regulation of endothelial cell chemotaxis
Cellular Component
GO:0000139 Golgi membrane
GO:0001669 acrosomal vesicle
GO:0001726 ruffle
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0043235 receptor complex
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148400
View Gene Order
ENSBTAG00000022799
Not yet available
Pathways
NETPATH
REACTOME
REACT_196643
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_189085
Disease pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_223683
Notch-HLH transcription pathway pathway
REACT_222486
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_196492
Pre-NOTCH Processing in the Endoplasmic Reticulum pathway
REACT_196494
Pre-NOTCH Expression and Processing pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_268602
Pre-NOTCH Transcription and Translation pathway
REACT_196638
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_233572
Gene Expression pathway
REACT_188576
Developmental Biology pathway
REACT_196604
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
REACT_196517
Pre-NOTCH Processing in Golgi pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_205507
Regulation of beta-cell development pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
mmu04330
Notch signaling pathway pathway
mmu05020
Prion diseases pathway
mmu04320
Dorso-ventral axis formation pathway
INOH
INOH website
Notch signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_118722
Pre-NOTCH Processing in the Endoplasmic Reticulum pathway
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_160089
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_160106
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160305
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_14835
Notch-HLH transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_13673
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_13698
Regulation of beta-cell development pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa04330
Notch signaling pathway pathway
hsa04320
Dorso-ventral axis formation pathway
hsa05020
Prion diseases pathway
INOH
INOH website
Notch signaling pathway pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
hes_heypathway
Notch-mediated HES/HEY network
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290610
RefSeq NM_008714
OMIM
CCDS CCDS15806
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca