Version 5.4
Mus musculus Protein: Notch1
Summary
InnateDB Protein IDBP-540383.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Notch1
Protein Name Notch gene homolog 1 (Drosophila)
Synonyms 9930111A19Rik; lin-12; Mis6; N1; Tan1;
Species Mus musculus
Ensembl Protein ENSMUSP00000115258
InnateDB Gene IDBG-149571 (Notch1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 181 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 39 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 181 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0002040 sprouting angiogenesis
GO:0002437 inflammatory response to antigenic stimulus
GO:0003219 cardiac right ventricle formation
GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007368 determination of left/right symmetry
GO:0007386 compartment pattern specification
GO:0007409 axonogenesis
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008544 epidermis development
GO:0009912 auditory receptor cell fate commitment
GO:0010001 glial cell differentiation
GO:0010468 regulation of gene expression
GO:0014807 regulation of somitogenesis
GO:0021915 neural tube development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030900 forebrain development
GO:0031069 hair follicle morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035914 skeletal muscle cell differentiation
GO:0042640 anagen
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048103 somatic stem cell division
GO:0048663 neuron fate commitment
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060548 negative regulation of cell death
GO:0060740 prostate gland epithelium morphogenesis
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0072602 interleukin-4 secretion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0043235 receptor complex
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID MGI:97363
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2AIX5
UniProt Splice Variant
Entrez Gene 18128
UniGene Mm.290610
RefSeq
MGI ID
MGI Symbol Notch1
OMIM
CCDS
HPRD
IMGT
EMBL AL732541
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca