Version 5.4
Mus musculus Gene: Pknox2
Summary
InnateDB Gene IDBG-149671.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pknox2
Gene Name Pbx/knotted 1 homeobox 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035934
Encoded Proteins
IDBP-149673
Pbx/knotted 1 homeobox 2
IDBP-149675
Pbx/knotted 1 homeobox 2
IDBP-742181
IDBP-787899
Pbx/knotted 1 homeobox 2
IDBP-741942
IDBP-787900
Pbx/knotted 1 homeobox 2
IDBP-787901
Pbx/knotted 1 homeobox 2
IDBP-787902
Pbx/knotted 1 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165495:
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:36890982-37147322
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000080754 ENSMUSP00000079578
ENSMUST00000039674 ENSMUSP00000035806
ENSMUST00000177218 ENSMUSP00000135581
ENSMUST00000175938 ENSMUSP00000138866
ENSMUST00000177444 ENSMUSP00000135641
ENSMUST00000177080
ENSMUST00000176622
ENSMUST00000176562
ENSMUST00000188348 ENSMUSP00000139976
ENSMUST00000188057 ENSMUSP00000140793
ENSMUST00000189294 ENSMUSP00000139728
ENSMUST00000188433
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003785 actin monomer binding
GO:0043565 sequence-specific DNA binding
GO:0051015 actin filament binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165495
View Gene Order
ENSBTAG00000000052
Not yet available
Cross-References
SwissProt Q8BG99
TrEMBL V9GWW7
UniProt Splice Variant
Entrez Gene 208076
UniGene Mm.260335 Mm.475393
RefSeq NM_001029838 NM_148950 XM_006510124 XM_006510125 XM_006510126 XM_006510127
OMIM
CCDS CCDS22974
HPRD
IMGT
MGI ID MGI:2445415
MGI Symbol Pknox2
EMBL AB086817 AC159884 AC164087 AF487460 AK082952 BC050865 CT009699
GenPept AAH50865 AAM18702 BAC20215 BAC38705
RNA Seq Atlas 208076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca