Version 5.4
Homo sapiens Gene: PKNOX2
Summary
InnateDB Gene IDBG-75435.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKNOX2
Gene Name PBX/knotted 1 homeobox 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165495
Encoded Proteins
IDBP-75437
PBX/knotted 1 homeobox 2
IDBP-592474
PBX/knotted 1 homeobox 2
IDBP-600767
PBX/knotted 1 homeobox 2
IDBP-597465
PBX/knotted 1 homeobox 2
IDBP-585948
PBX/knotted 1 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:125164687-125433389
Strand Forward strand
Band q24.2
Transcripts
ENST00000298282 ENSP00000298282
ENST00000530517
ENST00000531116
ENST00000559662
ENST00000557814
ENST00000527238 ENSP00000431599
ENST00000561399
ENST00000532623 ENSP00000434377
ENST00000531212 ENSP00000434255
ENST00000558729
ENST00000561115
ENST00000558705 ENSP00000453374
ENST00000561298
ENST00000526955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003785 actin monomer binding
GO:0043565 sequence-specific DNA binding
GO:0051015 actin filament binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035934
View Gene Order
ENSBTAG00000000052
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.278564
RefSeq NM_022062 XM_005271642 XM_005271643 XM_006718895
HUGO
OMIM
CCDS CCDS41730
HPRD 17857
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca