InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bmpr1a

Summary

InnateDB Gene

IDBG-149689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmpr1a

Gene Name

bone morphogenetic protein receptor, type 1A

Synonyms

1110037I22Rik; ALK3; AU045487; Bmpr; BMPR-IA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021796

Encoded Proteins

IDBP-149691

bone morphogenetic protein receptor, type 1A

IDBP-625013

bone morphogenetic protein receptor, type 1A

IDBP-625014

bone morphogenetic protein receptor, type 1A

IDBP-625015

bone morphogenetic protein receptor, type 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107779:
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:34410734-34503341

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049005	ENSMUSP00000035900
ENSMUST00000165280	ENSMUSP00000131984
ENSMUST00000171343	ENSMUSP00000126852
ENSMUST00000171551	ENSMUSP00000129927

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001707	mesoderm formation
GO:0001756	somitogenesis
GO:0001880	Mullerian duct regression
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003007	heart morphogenesis
GO:0003272	endocardial cushion formation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0007389	pattern specification process
GO:0007398	ectoderm development
GO:0007399	nervous system development
GO:0007492	endoderm development
GO:0007507	heart development
GO:0009950	dorsal/ventral axis specification
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014032	neural crest cell development
GO:0019827	stem cell maintenance
GO:0021983	pituitary gland development
GO:0021998	neural plate mediolateral regionalization
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0035137	hindlimb morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0045669	positive regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048339	paraxial mesoderm development
GO:0048352	paraxial mesoderm structural organization
GO:0048368	lateral mesoderm development
GO:0048378	regulation of lateral mesodermal cell fate specification
GO:0048382	mesendoderm development
GO:0048568	embryonic organ development
GO:0048589	developmental growth
GO:0048598	embryonic morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050768	negative regulation of neurogenesis
GO:0051216	cartilage development
GO:0060021	palate development
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060896	neural plate pattern specification
GO:0060914	heart formation