Version 5.4
Mus musculus Protein: Bmpr1a
Summary
InnateDB Protein IDBP-625013.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bmpr1a
Protein Name bone morphogenetic protein receptor, type 1A
Synonyms 1110037I22Rik; ALK3; AU045487; Bmpr; BMPR-IA;
Species Mus musculus
Ensembl Protein ENSMUSP00000131984
InnateDB Gene IDBG-149689 (Bmpr1a)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0046332 SMAD binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001880 Mullerian duct regression
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003007 heart morphogenesis
GO:0003272 endocardial cushion formation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007389 pattern specification process
GO:0007398 ectoderm development
GO:0007399 nervous system development
GO:0007492 endoderm development
GO:0007507 heart development
GO:0009950 dorsal/ventral axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014032 neural crest cell development
GO:0019827 stem cell maintenance
GO:0021983 pituitary gland development
GO:0021998 neural plate mediolateral regionalization
GO:0023014 signal transduction by phosphorylation
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0035137 hindlimb morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048339 paraxial mesoderm development
GO:0048352 paraxial mesoderm structural organization
GO:0048368 lateral mesoderm development
GO:0048378 regulation of lateral mesodermal cell fate specification
GO:0048382 mesendoderm development
GO:0048568 embryonic organ development
GO:0048589 developmental growth
GO:0048598 embryonic morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0051216 cartilage development
GO:0060021 palate development
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060896 neural plate pattern specification
GO:0060914 heart formation
Cellular Component
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:1338938
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF01064
PF00069
PF07714
PF08515
PRINTS PR00109
PIRSF
SMART SM00220
SM00467
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q60607
UniProt Splice Variant
Entrez Gene 12166
UniGene Mm.472395
RefSeq
MGI ID
MGI Symbol Bmpr1a
OMIM
CCDS
HPRD
IMGT
EMBL AC160930 AC166105 U04673
GenPept AAA21515

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca