InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vps37a

Summary

InnateDB Gene

IDBG-149879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps37a

Gene Name

vacuolar protein sorting 37A (yeast)

Synonyms

2210018P21Rik; 4930592A21Rik; AW261445; D8Ertd531e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031600

Encoded Proteins

IDBP-149881

vacuolar protein sorting 37A (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155975:
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:40511783-40551134

Strand

Forward strand

Band

Transcripts

ENSMUST00000098817

ENSMUSP00000096415

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0015031	protein transport
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Cellular Component

GO:0000813	ESCRT I complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0031902	late endosome membrane
GO:0043231	intracellular membrane-bounded organelle