Version 5.4
Mus musculus Gene: Bcl6
Summary
InnateDB Gene IDBG-149890.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl6
Gene Name B cell leukemia/lymphoma 6
Synonyms Bcl5
Species Mus musculus
Ensembl Gene ENSMUSG00000022508
Encoded Proteins
IDBP-149892
B-cell leukemia/lymphoma 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113916:
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23965052-23988852
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000023151 ENSMUSP00000023151
ENSMUST00000135352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 131 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 10 [view]
Protein-DNA 15 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 131 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002467 germinal center formation
GO:0002829 negative regulation of type 2 immune response
GO:0006351 transcription, DNA-templated
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0007266 Rho protein signal transduction
GO:0007283 spermatogenesis
GO:0008104 protein localization
GO:0008285 negative regulation of cell proliferation
GO:0030036 actin cytoskeleton organization
GO:0030183 B cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030890 positive regulation of B cell proliferation
GO:0032319 regulation of Rho GTPase activity
GO:0032764 negative regulation of mast cell cytokine production
GO:0035024 negative regulation of Rho protein signal transduction
GO:0042092 type 2 immune response
GO:0042127 regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043380 regulation of memory T cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048821 erythrocyte development
GO:0050727 regulation of inflammatory response
GO:0051272 positive regulation of cellular component movement
Cellular Component
GO:0005634 nucleus
GO:0005657 replication fork
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113916
View Gene Order
ENSBTAG00000001511
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
foxopathway
FoxO family signaling
hdac_classii_pathway
Signaling events mediated by HDAC Class II
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P41183
TrEMBL Q544F9
UniProt Splice Variant
Entrez Gene 12053
UniGene Mm.347398 Mm.455295 Mm.473025
RefSeq NM_009744 XM_006521722
OMIM
CCDS CCDS28082
HPRD
IMGT
MGI ID MGI:107187
MGI Symbol Bcl6
EMBL AK039228 AK151229 BC052315 CH466521 D38377 U41465
GenPept AAB17432 AAH52315 BAA07456 BAC30286 BAE30221 EDK97676
RNA Seq Atlas 12053

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca