Version 5.4
Homo sapiens Gene: BCL6
Summary
InnateDB Gene IDBG-69349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL6
Gene Name B-cell CLL/lymphoma 6
Synonyms BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Species Homo sapiens
Ensembl Gene ENSG00000113916
Encoded Proteins
IDBP-69351
B-cell CLL/lymphoma 6
IDBP-293546
B-cell CLL/lymphoma 6
IDBP-386509
B-cell CLL/lymphoma 6
IDBP-386511
B-cell CLL/lymphoma 6
IDBP-386514
B-cell CLL/lymphoma 6
IDBP-386515
B-cell CLL/lymphoma 6
IDBP-808960
B-cell CLL/lymphoma 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:187721377-187745727
Strand Reverse strand
Band q27.3
Transcripts
ENST00000232014 ENSP00000232014
ENST00000406870 ENSP00000384371
ENST00000419510 ENSP00000398014
ENST00000450123 ENSP00000413122
ENST00000430339 ENSP00000415574
ENST00000438077 ENSP00000414455
ENST00000479110
ENST00000480458
ENST00000470319
ENST00000496823
ENST00000621333 ENSP00000479784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 201 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 201 [view]
Protein-Protein 151 [view]
Protein-DNA 48 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002467 germinal center formation
GO:0002634 regulation of germinal center formation
GO:0002829 negative regulation of type 2 immune response
GO:0002903 negative regulation of B cell apoptotic process
GO:0006351 transcription, DNA-templated
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0007266 Rho protein signal transduction
GO:0007283 spermatogenesis
GO:0008104 protein localization
GO:0008285 negative regulation of cell proliferation
GO:0030036 actin cytoskeleton organization
GO:0030183 B cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030890 positive regulation of B cell proliferation
GO:0032319 regulation of Rho GTPase activity
GO:0032764 negative regulation of mast cell cytokine production
GO:0035024 negative regulation of Rho protein signal transduction
GO:0042092 type 2 immune response
GO:0042127 regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043380 regulation of memory T cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048821 erythrocyte development
GO:0050727 regulation of inflammatory response
GO:0050776 regulation of immune response
GO:0051272 positive regulation of cellular component movement
Cellular Component
GO:0005634 nucleus
GO:0005657 replication fork
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022508
View Gene Order
ENSBTAG00000001511
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
foxopathway
FoxO family signaling
hdac_classii_pathway
Signaling events mediated by HDAC Class II
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478588 Hs.711290
RefSeq NM_001130845 NM_001134738 NM_001706 XM_005247694
HUGO
OMIM
CCDS CCDS3289 CCDS46975
HPRD 00180
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca