InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lpp

Summary

InnateDB Gene

IDBG-149949.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpp

Gene Name

LIM domain containing preferred translocation partner in lipoma

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033306

Encoded Proteins

IDBP-149951

LIM domain containing preferred translocation partner in lipoma

IDBP-150050

LIM domain containing preferred translocation partner in lipoma

IDBP-249895

LIM domain containing preferred translocation partner in lipoma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145012:
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of chimeric proteins that may promote tumor growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:24393350-24992576

Strand

Forward strand

Band

Transcripts

ENSMUST00000038053	ENSMUSP00000036304
ENSMUST00000078988	ENSMUSP00000078005
ENSMUST00000115314	ENSMUSP00000110969

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005925	focal adhesion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000145012

View Gene Order

ENSBTAG00000044001

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

ecadherin_stabilization_pathway

Stabilization and expansion of the E-cadherin adherens junction

Cross-References

SwissProt

Q8BFW7

TrEMBL

UniProt Splice Variant

Entrez Gene

210126

UniGene

Mm.209385 Mm.391933 Mm.410711

RefSeq

NM_001145952 NM_001145954 NM_178665 XM_006521957

OMIM

CCDS

CCDS28083 CCDS49807

HPRD

IMGT

MGI ID

MGI:2441849

MGI Symbol

Lpp

EMBL

AK029335 AK029567 AK040643 AK045288 AK045341 AK051345 AK051937 AK054550 AK076989 AK169780 BC085321

GenPept

AAH85321 BAC26401 BAC26516 BAC30654 BAC32298 BAC32316 BAC34608 BAC34815 BAC35821 BAC36552 BAE41362

RNA Seq Atlas

210126