Version 5.4
Mus musculus Protein: Lpp
Summary
InnateDB Protein IDBP-149951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpp
Protein Name LIM domain containing preferred translocation partner in lipoma
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036304
InnateDB Gene IDBG-149949 (Lpp)
Protein Structure
UniProt Annotation
Function May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction {ECO:0000250}. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID MGI:2441849
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BFW7
PhosphoSite PhosphoSite-Q8BFW7
TrEMBL
UniProt Splice Variant
Entrez Gene 210126
UniGene Mm.410711
RefSeq NP_848780
MGI ID
MGI Symbol Lpp
OMIM
CCDS CCDS28083
HPRD
IMGT
EMBL AK029335 AK029567 AK040643 AK045288 AK045341 AK051345 AK051937 AK054550 AK076989 AK169780 BC085321
GenPept AAH85321 BAC26401 BAC26516 BAC30654 BAC32298 BAC32316 BAC34608 BAC34815 BAC35821 BAC36552 BAE41362

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca