InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Esr2

Summary

InnateDB Gene

IDBG-150083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esr2

Gene Name

estrogen receptor 2 (beta)

Synonyms

ER[b]; ERbeta; Estrb

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021055

Encoded Proteins

IDBP-150085

estrogen receptor 2 (beta)

IDBP-150087

estrogen receptor 2 (beta)

IDBP-260313

estrogen receptor 2 (beta)

IDBP-787993

estrogen receptor 2 (beta)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140009:
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:76120419-76177259

Strand

Reverse strand

Band

Transcripts

ENSMUST00000101291	ENSMUSP00000098849
ENSMUST00000076634	ENSMUSP00000075932
ENSMUST00000110421	ENSMUSP00000106051
ENSMUST00000133564	ENSMUSP00000138637

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0030284	estrogen receptor activity
GO:0034056	estrogen response element binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001541	ovarian follicle development
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008628	hormone-mediated apoptotic signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0043401	steroid hormone mediated signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060740	prostate gland epithelium morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development
GO:0060766	negative regulation of androgen receptor signaling pathway