Version 5.4
Homo sapiens Gene: ESR2
Summary
InnateDB Gene IDBG-9004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESR2
Gene Name estrogen receptor 2 (ER beta)
Synonyms ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2
Species Homo sapiens
Ensembl Gene ENSG00000140009
Encoded Proteins
IDBP-9006
estrogen receptor 2 (ER beta)
IDBP-9008
estrogen receptor 2 (ER beta)
IDBP-9012
estrogen receptor 2 (ER beta)
IDBP-9014
estrogen receptor 2 (ER beta)
IDBP-9016
estrogen receptor 2 (ER beta)
IDBP-596023
estrogen receptor 2 (ER beta)
IDBP-600463
estrogen receptor 2 (ER beta)
IDBP-594342
estrogen receptor 2 (ER beta)
IDBP-585884
estrogen receptor 2 (ER beta)
IDBP-598270
estrogen receptor 2 (ER beta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:64084232-64338112
Strand Reverse strand
Band q23.3
Transcripts
ENST00000358599 ENSP00000351412
ENST00000353772 ENSP00000335551
ENST00000341099 ENSP00000343925
ENST00000267525 ENSP00000267525
ENST00000344288 ENSP00000345616
ENST00000556275 ENSP00000452485
ENST00000554572 ENSP00000450699
ENST00000555278 ENSP00000450488
ENST00000553796 ENSP00000452426
ENST00000557772 ENSP00000451582
ENST00000555483
ENST00000554520
ENST00000555783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 111 [view]
Protein-Protein 110 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0030284 estrogen receptor activity
GO:0034056 estrogen response element binding
GO:0043565 sequence-specific DNA binding
GO:0048019 receptor antagonist activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001541 ovarian follicle development
GO:0001764 neuron migration
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0010467 gene expression
GO:0030308 negative regulation of cell growth
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0043401 steroid hormone mediated signaling pathway
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065 uterus development
GO:0060068 vagina development
GO:0060740 prostate gland epithelium morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:1900116 extracellular negative regulation of signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021055
View Gene Order
ENSBTAG00000004498
Not yet available
Pathways
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
erb_genomic_pathway
Validated nuclear estrogen receptor beta network
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.660607
RefSeq NM_001040275 NM_001214902 NM_001214903 NM_001271876 NM_001271877 NM_001291712 NM_001437
HUGO
OMIM
CCDS CCDS32096 CCDS55920 CCDS61469 CCDS61470 CCDS9762
HPRD 03390
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca