Version 5.4
Mus musculus Gene: Rfx6
Summary
InnateDB Gene IDBG-150403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfx6
Gene Name regulatory factor X, 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000019900
Encoded Proteins
IDBP-150407
regulatory factor X, 6
IDBP-538750
regulatory factor X, 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185002:
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:51677756-51730429
Strand Forward strand
Band B3
Transcripts
ENSMUST00000050455 ENSMUSP00000057384
ENSMUST00000125729
ENSMUST00000122922 ENSMUSP00000116057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0003309 type B pancreatic cell differentiation
GO:0003310 pancreatic A cell differentiation
GO:0003311 pancreatic D cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0031018 endocrine pancreas development
GO:0042593 glucose homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050796 regulation of insulin secretion
GO:0090104 pancreatic E cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185002
View Gene Order
ENSBTAG00000000264
Not yet available
Cross-References
SwissProt Q8C7R7
TrEMBL
UniProt Splice Variant
Entrez Gene 320995
UniGene Mm.109190
RefSeq NM_001159389 NM_177306
OMIM
CCDS CCDS23835 CCDS48558
HPRD
IMGT
MGI ID MGI:2445208
MGI Symbol Rfx6
EMBL AC153527 AK029809 AK049380 BC132104 BC132294
GenPept AAI32105 AAI32295 BAC26627 BAC33722
RNA Seq Atlas 320995

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca