Version 5.4
Mus musculus Protein: Rfx6
Summary
InnateDB Protein IDBP-150407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfx6
Protein Name regulatory factor X, 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000057384
InnateDB Gene IDBG-150403 (Rfx6)
Protein Structure
UniProt Annotation
Function Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. {ECO:0000269PubMed:20148032}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00858, ECO:0000269PubMed:20148032}.
Disease Associations
Tissue Specificity In the adult pancreas, expression is restricted to the islets where it could be detected in all endocrine lineages. {ECO:0000269PubMed:20040487, ECO:0000269PubMed:20148032}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0003309 type B pancreatic cell differentiation
GO:0003310 pancreatic A cell differentiation
GO:0003311 pancreatic D cell differentiation
GO:0006351 transcription, DNA-templated
GO:0042593 glucose homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050796 regulation of insulin secretion
GO:0090104 pancreatic E cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2445208
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C7R7
PhosphoSite PhosphoSite-Q8C7R7
TrEMBL
UniProt Splice Variant
Entrez Gene 320995
UniGene Mm.109190
RefSeq NP_796280
MGI ID
MGI Symbol Rfx6
OMIM
CCDS CCDS23835
HPRD
IMGT
EMBL AC153527 AK029809 AK049380 BC132104 BC132294
GenPept AAI32105 AAI32295 BAC26627 BAC33722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca