Version 5.4
Mus musculus Gene: Tcof1
Summary
InnateDB Gene IDBG-150420.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcof1
Gene Name Treacher Collins Franceschetti syndrome 1, homolog
Synonyms AA408847; AW209012; treacle
Species Mus musculus
Ensembl Gene ENSMUSG00000024613
Encoded Proteins
IDBP-622988
Treacher Collins Franceschetti syndrome 1, homolog
IDBP-702711
IDBP-702555
IDBP-702624
IDBP-702568
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070814:
This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:60813755-60848971
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000163446 ENSMUSP00000130454
ENSMUST00000176630 ENSMUSP00000135476
ENSMUST00000176088
ENSMUST00000177172 ENSMUSP00000134755
ENSMUST00000175934 ENSMUSP00000135639
ENSMUST00000177343 ENSMUSP00000135295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006810 transport
GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070814
View Gene Order
ENSBTAG00000015224
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.443372 Mm.446728 Mm.486251
RefSeq NM_001198984 NM_011552 XM_006525777 XM_006525779
OMIM
CCDS CCDS37836 CCDS57125
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca