Version 5.4
Mus musculus Protein: Tcof1
Summary
InnateDB Protein IDBP-702711.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcof1
Protein Name
Synonyms AA408847; AW209012; treacle;
Species Mus musculus
Ensembl Protein ENSMUSP00000135476
InnateDB Gene IDBG-150420 (Tcof1)
Protein Structure
UniProt Annotation
Function May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex. May participate in certain stages of ribosome biogenesis.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous in adult and embryonic tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006810 transport
GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:892003
InterPro IPR003993 Treacher Collins syndrome, treacle
IPR006594 LisH dimerisation motif
IPR017859 Treacle-like, Treacher Collins Syndrome
PFAM PF03546
PRINTS PR01503
PIRSF
SMART SM00667
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08784
PhosphoSite PhosphoSite-O08784
TrEMBL
UniProt Splice Variant
Entrez Gene 21453
UniGene Mm.486251
RefSeq NP_035682
MGI ID
MGI Symbol Tcof1
OMIM
CCDS CCDS37836
HPRD
IMGT
EMBL AF001794 BC060105 U81030
GenPept AAB60933 AAB71347 AAH60105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca