Version 5.4
Mus musculus Gene: Ros1
Summary
InnateDB Gene IDBG-150588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ros1
Gene Name Ros1 proto-oncogene
Synonyms c-ros; Ros-1
Species Mus musculus
Ensembl Gene ENSMUSG00000019893
Encoded Proteins
IDBP-150590
Ros1 proto-oncogene
IDBP-401349
Ros1 proto-oncogene
IDBP-710939
IDBP-712364
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047936:
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:52045721-52195244
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000020045 ENSMUSP00000020045
ENSMUST00000117992 ENSMUSP00000112873
ENSMUST00000175892 ENSMUSP00000135235
ENSMUST00000177378 ENSMUSP00000134905
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
Biological Process
GO:0002066 columnar/cuboidal epithelial cell development
GO:0006468 protein phosphorylation
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0010629 negative regulation of gene expression
GO:0010966 regulation of phosphate transport
GO:0016049 cell growth
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0032006 regulation of TOR signaling
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000047936
View Gene Order
ENSBTAG00000047600
Not yet available
Cross-References
SwissProt
TrEMBL H3BK36
UniProt Splice Variant
Entrez Gene 19886
UniGene Mm.236163
RefSeq NM_011282 XM_006512625
OMIM
CCDS CCDS23838
HPRD
IMGT
MGI ID MGI:97999
MGI Symbol Ros1
EMBL AC153950 AC155831
GenPept
RNA Seq Atlas 19886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca