InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fgf12

Summary

InnateDB Gene

IDBG-150770.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgf12

Gene Name

fibroblast growth factor 12

Synonyms

AV114868; FGF-12; FHF-1; Fhf1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022523

Encoded Proteins

IDBP-150772

fibroblast growth factor 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114279:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:28160120-28445227

Strand

Reverse strand

Band

Transcripts

ENSMUST00000100024

ENSMUSP00000097601

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding

Biological Process

GO:0003254	regulation of membrane depolarization
GO:0007254	JNK cascade
GO:0007268	synaptic transmission
GO:0008344	adult locomotory behavior
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010765	positive regulation of sodium ion transport
GO:0050905	neuromuscular process
GO:1902305	regulation of sodium ion transmembrane transport
GO:2000649	regulation of sodium ion transmembrane transporter activity
GO:2001258	negative regulation of cation channel activity

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000114279

View Gene Order

ENSBTAG00000012413

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05218

Melanoma pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04010

MAPK signaling pathway pathway

mmu05200

Pathways in cancer pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04010

MAPK signaling pathway pathway

hsa05218

Melanoma pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

P61329

TrEMBL

UniProt Splice Variant

Entrez Gene

14167

UniGene

Mm.396759 Mm.405910 Mm.7996

RefSeq

NM_001276419 NM_010199 NM_183064 XM_006521793

OMIM

CCDS

CCDS28092

HPRD

IMGT

MGI ID

MGI:109183

MGI Symbol

Fgf12

EMBL

AF020738 AK034335 BC030485 U66201

GenPept

AAB18917 AAB71607 AAH30485 BAC28679

RNA Seq Atlas

14167