InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGF12

Summary

InnateDB Gene

IDBG-69854.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF12

Gene Name

fibroblast growth factor 12

Synonyms

FGF12B; FHF1

Species

Homo sapiens

Ensembl Gene

ENSG00000114279

Encoded Proteins

IDBP-386663

fibroblast growth factor 12

IDBP-386664

fibroblast growth factor 12

IDBP-386665

fibroblast growth factor 12

IDBP-386666

fibroblast growth factor 12

IDBP-386667

fibroblast growth factor 12

IDBP-386669

fibroblast growth factor 12

IDBP-386671

fibroblast growth factor 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:192139395-192767764

Strand

Reverse strand

Band

q29

Transcripts

ENST00000454309	ENSP00000413496
ENST00000445105	ENSP00000393686
ENST00000440901	ENSP00000400948
ENST00000450716	ENSP00000397635
ENST00000430714	ENSP00000410125
ENST00000448795	ENSP00000412904
ENST00000418610	ENSP00000395517
ENST00000466144
ENST00000491636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding

Biological Process

GO:0003254	regulation of membrane depolarization
GO:0007165	signal transduction
GO:0007254	JNK cascade
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0007507	heart development
GO:0008344	adult locomotory behavior
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010765	positive regulation of sodium ion transport
GO:0050905	neuromuscular process
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:1902305	regulation of sodium ion transmembrane transport
GO:2000649	regulation of sodium ion transmembrane transporter activity
GO:2001258	negative regulation of cation channel activity

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022523

View Gene Order

ENSBTAG00000012413

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04010

MAPK signaling pathway pathway

hsa05218

Melanoma pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

P61328

TrEMBL

C9JUK8

UniProt Splice Variant

Entrez Gene

2257

UniGene

Hs.390250 Hs.584758

RefSeq

NM_021032 NM_004113 XM_005247227 XM_006713538 XM_006713539

HUGO

HGNC:3668

OMIM

601513

CCDS

CCDS3301 CCDS46983

HPRD

03303

IMGT

EMBL

AC026671 AC073363 AC079623 AC079847 AC128710 AK125307 AK312513 AK313671 BC022524 CH471052 U66197 U76381

GenPept

AAB18786 AAB18913 AAH22524 BAG35414 BAG36423 BAG54181 EAW78084

RNA Seq Atlas

2257