Version 5.4
Mus musculus Gene: Col3a1
Summary
InnateDB Gene IDBG-150792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col3a1
Gene Name collagen, type III, alpha 1
Synonyms AW550625; Col3a-1; mKIAA4231; MMS10-W; Ms10w
Species Mus musculus
Ensembl Gene ENSMUSG00000026043
Encoded Proteins
IDBP-150794
collagen, type III, alpha 1
IDBP-788955
collagen, type III, alpha 1
IDBP-788957
collagen, type III, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168542:
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:45311538-45349706
Strand Forward strand
Band C1.1
Transcripts
ENSMUST00000087883 ENSMUSP00000085192
ENSMUST00000129611
ENSMUST00000123204
ENSMUST00000189818
ENSMUST00000190943
ENSMUST00000185687 ENSMUSP00000139894
ENSMUST00000186021 ENSMUSP00000139802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001501 skeletal system development
GO:0001568 blood vessel development
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0007568 aging
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0018149 peptide cross-linking
GO:0021987 cerebral cortex development
GO:0030199 collagen fibril organization
GO:0032964 collagen biosynthetic process
GO:0034097 response to cytokine
GO:0035025 positive regulation of Rho protein signal transduction
GO:0042060 wound healing
GO:0043206 extracellular fibril organization
GO:0043588 skin development
GO:0048565 digestive tract development
GO:0050777 negative regulation of immune response
GO:0071230 cellular response to amino acid stimulus
GO:2001223 negative regulation of neuron migration
Cellular Component
GO:0005581 collagen trimer
GO:0005586 collagen type III
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168542
View Gene Order
ENSBTAG00000021466
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_196644
Syndecan interactions pathway
REACT_236183
NCAM1 interactions pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_196581
Scavenging by Class A Receptors pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_188257
Signal Transduction pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04510
Focal adhesion pathway
mmu05146
Amoebiasis pathway
mmu04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_16888
Signaling by PDGF pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_163942
Syndecan interactions pathway
REACT_18266
Axon guidance pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_120729
Collagen formation pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05146
Amoebiasis pathway
hsa04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
endothelinpathway
Endothelins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 12825
UniGene
RefSeq NM_009930
OMIM
CCDS CCDS35554
HPRD
IMGT
MGI ID MGI:88453
MGI Symbol Col3a1
EMBL
GenPept
RNA Seq Atlas 12825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca