Bos taurus Gene: BT.64714

Summary
InnateDB Gene IDBG-639630.2
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol BT.64714
Gene Name collagen alpha-1(III) chain precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021466
Encoded Proteins
IDBP-691838 collagen alpha-1(III) chain
IDBP-691841 collagen alpha-1(III) chain
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168542:
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 7318227-7356937
Strand Reverse strand
Band 0
Transcripts
ENSBTAT00000028617  ENSBTAP00000028617
ENSBTAT00000038678  ENSBTAP00000038490
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
 
Predicted by orthology
Total 14 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0046332 SMAD binding
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001568 blood vessel development
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0009314 response to radiation
GO:0018149 peptide cross-linking
GO:0030199 collagen fibril organization
GO:0032964 collagen biosynthetic process
GO:0034097 response to cytokine stimulus
GO:0042060 wound healing
GO:0043206 fibril organization
GO:0043588 skin development
GO:0048565 digestive tract development
GO:0050777 negative regulation of immune response
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005581 collagen
GO:0005586 collagen type III
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSG00000168542 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSMUSG00000026043 Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121139 Collagen biosynthesis and modifying enzymes
KEGG
hsa05146  Amoebiasis
hsa04512  ECM-receptor interaction
hsa04510  Focal adhesion
hsa04974  Protein digestion and absorption
INOH
INOH website Integrin signaling pathway
PID BIOCARTA
PID NCI
integrin1_pathway Beta1 integrin cell surface interactions
endothelinpathway Endothelins
Cross-References
SwissProt
TrEMBL F1MXS8 F1N2Y4
UniProt Splice Variant
Entrez Gene 510833 
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003919 DAAA02003920
GenPept
ImmGen BT.64714 (murine) 
RNA Seq Atlas 510833 
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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