Version 5.4
Mus musculus Gene: Sardh
Summary
InnateDB Gene IDBG-150888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sardh
Gene Name sarcosine dehydrogenase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000009614
Encoded Proteins
IDBP-150890
sarcosine dehydrogenase
IDBP-539622
sarcosine dehydrogenase
IDBP-542366
sarcosine dehydrogenase
IDBP-532238
sarcosine dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123453:
This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27188393-27248337
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000102886 ENSMUSP00000099950
ENSMUST00000091224
ENSMUST00000142136
ENSMUST00000156434
ENSMUST00000127805
ENSMUST00000147089
ENSMUST00000144448
ENSMUST00000149733 ENSMUSP00000120478
ENSMUST00000139312 ENSMUSP00000119866
ENSMUST00000129975 ENSMUSP00000120170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004047 aminomethyltransferase activity
GO:0008480 sarcosine dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006546 glycine catabolic process
GO:0032259 methylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123453
View Gene Order
ENSBTAG00000004510
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.278467 Mm.481288
RefSeq NM_138665 XM_006497788 XM_006497789
OMIM
CCDS CCDS15826
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca