Version 5.4
Mus musculus Gene: Top1mt
Summary
InnateDB Gene IDBG-151097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Top1mt
Gene Name DNA topoisomerase 1, mitochondrial
Synonyms 2900052H09Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000000934
Encoded Proteins
IDBP-151099
DNA topoisomerase 1, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184428:
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:75657035-75678800
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000000958 ENSMUSP00000000958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I activity
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006265 DNA topological change
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000184428
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.182401
RefSeq NM_028404 XM_006521466
OMIM
CCDS CCDS27547
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca