Version 5.4
Homo sapiens Gene: TOP1MT
Summary
InnateDB Gene IDBG-38317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP1MT
Gene Name topoisomerase (DNA) I, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184428
Encoded Proteins
IDBP-38319
topoisomerase (DNA) I, mitochondrial
IDBP-480939
topoisomerase (DNA) I, mitochondrial
IDBP-482100
topoisomerase (DNA) I, mitochondrial
IDBP-479686
topoisomerase (DNA) I, mitochondrial
IDBP-481870
topoisomerase (DNA) I, mitochondrial
IDBP-477272
topoisomerase (DNA) I, mitochondrial
IDBP-484134
topoisomerase (DNA) I, mitochondrial
IDBP-482401
topoisomerase (DNA) I, mitochondrial
IDBP-479860
topoisomerase (DNA) I, mitochondrial
IDBP-476128
topoisomerase (DNA) I, mitochondrial
IDBP-479524
topoisomerase (DNA) I, mitochondrial
IDBP-475198
topoisomerase (DNA) I, mitochondrial
IDBP-477248
topoisomerase (DNA) I, mitochondrial
IDBP-476548
topoisomerase (DNA) I, mitochondrial
IDBP-479272
topoisomerase (DNA) I, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143304384-143359979
Strand Reverse strand
Band q24.3
Transcripts
ENST00000329245 ENSP00000328835
ENST00000519977 ENSP00000427925
ENST00000517857
ENST00000521193 ENSP00000428369
ENST00000519148 ENSP00000429169
ENST00000523676 ENSP00000429181
ENST00000518951 ENSP00000428727
ENST00000519139 ENSP00000428451
ENST00000522041 ENSP00000427998
ENST00000519591 ENSP00000429177
ENST00000522121 ENSP00000430139
ENST00000523417 ENSP00000430679
ENST00000518007 ENSP00000430209
ENST00000518760 ENSP00000428723
ENST00000520950 ENSP00000430635
ENST00000522043 ENSP00000428931
ENST00000524092
ENST00000505857
ENST00000521024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I activity
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006265 DNA topological change
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000000934
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.528574 Hs.666002 Hs.734085 Hs.736862
RefSeq NM_001258446 NM_001258447 NM_052963 XM_005250782
HUGO
OMIM
CCDS CCDS59115 CCDS6400
HPRD 16214
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca