InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gpx2

Summary

InnateDB Gene

IDBG-151265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpx2

Gene Name

glutathione peroxidase 2

Synonyms

GI-GPx; GPx-GI; GSHPx-2; GSHPx-GI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042808

Encoded Proteins

IDBP-151267

glutathione peroxidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Knockout studies in mice indicate that mRNA expression and activity of this enzyme are induced by luminal microflora, suggesting a role for this peroxidase in preventing inflammation in the GI tract. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:76792335-76795554

Strand

Reverse strand

Band

Transcripts

ENSMUST00000082431

ENSMUSP00000081012

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity

Biological Process

GO:0001659	temperature homeostasis
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0006979	response to oxidative stress
GO:0009609	response to symbiotic bacterium
GO:0051702	interaction with symbiont
GO:0055114	oxidation-reduction process