Version 5.4
Mus musculus Gene: Rxra
Summary
InnateDB Gene IDBG-151388.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rxra
Gene Name retinoid X receptor alpha
Synonyms 9530071D11Rik; Nr2b1; RXRalpha1
Species Mus musculus
Ensembl Gene ENSMUSG00000015846
Encoded Proteins
IDBP-151390
retinoid X receptor alpha
IDBP-151392
retinoid X receptor alpha
IDBP-252825
retinoid X receptor alpha
IDBP-533898
retinoid X receptor alpha
IDBP-621439
retinoid X receptor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20498053
Rxra controls innate inflammatory responses through the up-regulation of chemokine expression. Mice lacking Rxra in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
InnateDB Annotation from Orthologs
Summary
PMID 20498053
[Homo sapiens] RXRA controls innate inflammatory responses through the up-regulation of chemokine expression. Mice lacking RXRA in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186350:
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq, Jul 2008]
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27676440-27762957
Strand Forward strand
Band A3
Transcripts
ENSMUST00000077257 ENSMUSP00000076491
ENSMUST00000100251 ENSMUSP00000097822
ENSMUST00000113934 ENSMUSP00000109567
ENSMUST00000129514 ENSMUSP00000115165
ENSMUST00000148756
ENSMUST00000166775 ENSMUSP00000133044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 32 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 115 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004886 9-cis retinoic acid receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0031490 chromatin DNA binding
GO:0042809 vitamin D receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0044323 retinoic acid-responsive element binding
GO:0046982 protein heterodimerization activity
GO:0070644 vitamin D response element binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0001893 maternal placenta development
GO:0003007 heart morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0010629 negative regulation of gene expression
GO:0019048 modulation by virus of host morphology or physiology
GO:0032526 response to retinoic acid
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0043010 camera-type eye development
GO:0043401 steroid hormone mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048384 retinoic acid receptor signaling pathway
GO:0051289 protein homotetramerization
GO:0055007 cardiac muscle cell differentiation
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060038 cardiac muscle cell proliferation
GO:0060485 mesenchyme development
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0061032 visceral serous pericardium development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186350
View Gene Order
ENSBTAG00000017851
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_118837
Rora activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_232159
Cytochrome P450 - arranged by substrate type pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_200794
Mus musculus biological processes pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_241925
Circadian Clock pathway
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_239346
Recycling of bile acids and salts pathway
REACT_198352
REV-ERBA represses gene expression pathway
REACT_198351
RORA activates circadian gene expression pathway
REACT_226284
Regulation of pyruvate dehydrogenase (PDH) complex pathway
REACT_268398
Orphan transporters pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_227038
Endogenous sterols pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_203193
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_253080
Pyruvate metabolism pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_257268
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_196516
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_232343
Biological oxidations pathway
REACT_226440
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
mmu03320
PPAR signaling pathway pathway
mmu05216
Thyroid cancer pathway
mmu05222
Small cell lung cancer pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu05223
Non-small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
mmu04976
Bile secretion pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_15
IL3 pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11048
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_11042
Recycling of bile acids and salts pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12528
Regulation of pyruvate dehydrogenase (PDH) complex pathway
REACT_2071
Pyruvate metabolism pathway
REACT_13812
Endogenous sterols pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_267716
Orphan transporters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_71
Gene Expression pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05216
Thyroid cancer pathway
hsa05222
Small cell lung cancer pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04976
Bile secretion pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
rxr_vdr_pathway
RXR and RAR heterodimerization with other nuclear receptor
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24624 Mm.401401
RefSeq NM_001290481 NM_001290482 NM_011305 XM_006497801 XM_006497802 XM_006497803 XM_006497805
OMIM
CCDS CCDS15830 CCDS71011
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca