InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rxra

Summary

InnateDB Protein

IDBP-252825.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Rxra

Protein Name

retinoid X receptor alpha

Synonyms

9530071D11Rik; Nr2b1; RXRalpha1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109567

InnateDB Gene

IDBG-151388 (Rxra)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	32 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	115 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004886	9-cis retinoic acid receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0042809	vitamin D receptor binding
GO:0043565	sequence-specific DNA binding
GO:0044323	retinoic acid-responsive element binding
GO:0046982	protein heterodimerization activity
GO:0070644	vitamin D response element binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0001893	maternal placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0007566	embryo implantation
GO:0019048	modulation by virus of host morphology or physiology
GO:0032526	response to retinoic acid
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0043010	camera-type eye development
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060687	regulation of branching involved in prostate gland morphogenesis

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:98214

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding
IPR021780 Nuclear/hormone receptor activator site AF-1

PFAM

PF00104
PF00105
PF11825

PRINTS

PR00545
PR00047
PR00398
PR01282

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt