InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ube2i

Summary

InnateDB Gene

IDBG-151396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2i

Gene Name

ubiquitin-conjugating enzyme E2I

Synonyms

5830467E05Rik; F830028O17Rik; UBC9; Ubce2i; Ubce9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015120

Encoded Proteins

IDBP-151400

ubiquitin-conjugating enzyme E2I

IDBP-623666

ubiquitin-conjugating enzyme E2I

IDBP-623668

ubiquitin-conjugating enzyme E2I

IDBP-623670

ubiquitin-conjugating enzyme E2I

IDBP-623671

ubiquitin-conjugating enzyme E2I

IDBP-623672

ubiquitin-conjugating enzyme E2I

IDBP-623673

ubiquitin-conjugating enzyme E2I

IDBP-623674

ubiquitin-conjugating enzyme E2I

IDBP-623675

ubiquitin-conjugating enzyme E2I

IDBP-623677

ubiquitin-conjugating enzyme E2I

IDBP-623679

ubiquitin-conjugating enzyme E2I

IDBP-623680

ubiquitin-conjugating enzyme E2I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26348439

Baiap2l1 recruits Ube2i to sumoylate Pcbp2, which causes its cytoplasmic translocation during viral infection and the sumoylated Pcbp2 associates with Mavs to initiate its degradation, leading to downregulation of antiviral responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103275:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:25261916-25274622

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000049911	ENSMUSP00000055714
ENSMUST00000173084	ENSMUSP00000134261
ENSMUST00000173713	ENSMUSP00000134491
ENSMUST00000174216	ENSMUSP00000134546
ENSMUST00000172618	ENSMUSP00000134169
ENSMUST00000174031	ENSMUSP00000134350
ENSMUST00000174001	ENSMUSP00000134450
ENSMUST00000172569
ENSMUST00000173621	ENSMUSP00000134161
ENSMUST00000172868	ENSMUSP00000134540
ENSMUST00000172587	ENSMUSP00000133590
ENSMUST00000172520	ENSMUSP00000133311
ENSMUST00000173231	ENSMUSP00000133338
ENSMUST00000172462

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 280 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	280 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0016881	acid-amino acid ligase activity
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0043398	HLH domain binding
GO:0043425	bHLH transcription factor binding
GO:0044822	poly(A) RNA binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006464	cellular protein modification process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007275	multicellular organismal development
GO:0008152	metabolic process
GO:0010469	regulation of receptor activity
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0016925	protein sumoylation
GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0001650	fibrillar center
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016605	PML body
GO:0030425	dendrite
GO:0045202	synapse